Curriculum Vitae
Derick Hoskinson, Ph.D.
Chicago, IL 60640
312-871-8067 | derickhoskinson@gmail.com
Skills & Expertise
Core Expertise
Programming Languages
Project Management
Tools & Databases
Professional Experience
Senior Clinical Scientist
Tempus AI
Chicago, IL 60640
Mar 2019 - Mar 2027
- Created a tailored bed file to optimize genomic data analysis and facilitate the identification, classification, and clinical reporting of genetic variants on a large gene panel, resulting in improved accuracy and efficiency of downstream analysis.
- Contributed to the development and submission of the xT CDx assay to the FDA by curating and analyzing gene data to rank evidence per gene, ensuring accurate and effective clinical use.
- Played a vital role in the development and application of a new hereditary genetic testing panel, Tempus, xGv3 to identify germline variants in genes associated with hereditary cancer syndromes and incidental findings.
- Identified gaps and deficiencies in current workflows and executed new workflows and SOPs to harmonize variant classification across multiple institutions.
- Spearheaded the development and implementation of a reportable bed file solution for the Tempus xF assay, allowing for targeted reporting of specific genomic regions and improving the overall quality of data analysis.
- Used R programming language to design and implement a regions of interest bed file for reporting insertions and deletions for Tempus xF assay.
- Used R programming language to create, update, and modify curated data to justify the inclusion or exclusion of genomic regions for xT-oncology FDA application.
- Acted as the scientific lead in the development of the Tempus xF liquid biopsy panel to sequence and report SNVs and indels in clinically relevant regions of 105 genes plus CNVs and DNA rearrangements in a subset of these genes.
- Used R programming language to programmatically access data, wrangle data, analyze data and present data to implement changes in workflow or other internal processes.
Clinical Scientist
Tempus AI
Chicago, IL 60640
Jun 2017 - Mar 2019
- Evaluated data and analyzed variants for a project that led to the publication of the results in Nature BioTechnology.
- Trained over 20 M.A.s, Ph.D.s, and post-baccalaureates in germline and somatic variant classification.
- Worked closely with colleagues to build a team of variant scientists from 2 individuals to over 20 highly skilled variant scientists.
- Gained proficiency in the R programming language and experience using Python, JavaScript, HTML, and CSS.
Clinical Knowledge Curation Coordinator
Harvard Medical School, Partners Healthcare, Brigham and Women's Hospital
Cambridge, MA
Jun 2015 - Jun 2017
- Trained over 25 M.Ds, M.D./Ph.D.s, rotating fellows, undergraduates, and post-baccalaureates in constitutional variant classification.
- Assessed pathogenicity of variants from large gene panels covering cardiomyopathy, hearing loss, pulmonary disease, and Noonan syndrome.
- Evaluated data and assessed variants as a critical member of the Geisinger MyCode project including the 56 genes recommended by the ACMG and 20 additional genes from Geisinger.
- Extensive experience with population databases (1000 genomes, ESP, ExAC, gnomAD).
- Proficient in the use of variant databases including HGMD, ClinVar, LOVD, Deafness Variation database, Cardiodb, MitoMap, Leiden Muscular Dystrophy database, ARUP and COSMIC.
Medical Writer II
EBSCO Information Services, DynaMed
Ipswich, MA
Jun 2014 - Jun 2015
- Wrote evidence-based summaries of clinical trials aimed at serving as a resource for physicians and other health care professionals at the point of care.
- Wrote evidence-based point-of-care references for a number of clinically important disease topics.
- Critically assessed published clinical trials for methodological integrity.
- Critically assessed published clinical trials for inclusion in the DynaMed database in areas such as oncology, cardiology, infectious disease, endocrinology, and pediatrics.
- Applied in-depth knowledge of statistical methods to critically appraise clinical trials.
- Extensively worked in an XML environment to deliver point-of-care clinical information.
Education
Doctor of Philosophy Genetics
Tufts Graduate School of Biomedical Sciences
Sep 2006 - May 2014
Genetic & Genomic Analysis of the mRNA 3's End Processing Subunit Pcf11 Suggests an Expanded Role in Gene Expression.
- Utilized next-generation RNA sequencing to generate a large genome-wide dataset to measure changes in gene expression and potential impacts in cell viability under stress conditions.
- Performed bioinformatic analysis of whole genome sequencing data for the purpose of hypothesis testing.
- Proficient in the use of programs in the C/C++ environment, PERL script, and use of third-party programs for genetic analysis of large datasets.
- Coordinated the Genetics program student journal club to provide students exposure to an expansive range of genetic research topics.
- Supervised junior researchers in laboratory competency and facilitated development of critical-thinking and troubleshooting skills.
Bachelors of Science Biology & Psychology
University of Massachusetts Boston
Sep 2002 - May 2006
The function of Rom2 GDP/GTP exchange factor on RHO1 during sporulation in the budding yeast, Saccharomyces Cerevisiae.
- Performed genetic analysis including gene knockout and gene tagging of regulators of cell wall components.
Conferences
Comprehensive Whole Genome Sequencing (WGS) Assay Provides Diagnostic Insight into Clinically Relevant Genomic Alterations Across Myeloid Malignancies
AACR: American Association FOR Cancer Research 2025
Robert Huether PhD, Derick Hoskinson, Pavana Anur, Raul Torres PhD, Karl R. Beutner, Kristiyana Kaneva, Yan Yang, Kelly A. Potts, Andrew Frazier, Iris Braunstein, Brett Mahon MD, Michael A. Thompson MD PhD, Kate Sasser, PhD, Halla Nimeiri, MD, Lewis J. Kraft, PhD, Francisco M. De La Vega, Guillermo Garcia-Manero, MD
Detection of KMT2A Partial Tandem Duplication (PTD) in AML by Whole Genome Sequencing (WGS): Addressing Limitations of Traditional Techniques in the Era of Revumenib Approval
ASCO: American Society of Clinical Oncology 2025
Robert Huether, Derick Hoskinson, Pavana Anur, Raul Torres, Karl R. Beutner, Kristiyana Kaneva, Yan Yang, Kelly A. Potts, Andrew Frazier, Iris Braunstein, Brett Mahon, Michael A. Thompson, Kate Sasser, Halla Nimeiri, Lewis J. Kraft, Francisco M. De La Vega, Alejandro Marinos Velarde
Publications
Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response
Graber JH, Hoskinson D, Liu H, Kaczmarek Michaels K, Benson PS, Maki NJ, Wilson CL, McGrath C, Puleo F, Pearson E, Kuehner JN, Moore C
Genetics 2024 Feb 7;226(2)
Tumor Mutational Burden From Tumor-Only Sequencing Compared With Germline Subtraction From Paired Tumor and Normal Specimens
Parikh K, Huether R, White K, Hoskinson D, Beaubier N, Dong H, Adjei AA, Mansfield AS
JAMA Netw Open 2020 Feb 5;3(2):e200202
Considerations for clinical curation, classification, and reporting of low-penetrance and low effect size variants associated with disease risk
Senol-Cosar O, Schmidt RJ, Qian E, Hoskinson D, Mason-Suares H, Funke B, Lebo MS
Genet Med 2019 Dec;21(12):2765-2773
Integrated genomic profiling expands clinical options for patients with cancer
Beaubier N, Bontrager M, Huether R, Igartua C, Lau D, Tell R, Bobe AM, Bush S, Chang AL, Hoskinson DC, Khan AA, Kudalkar E, Leibowitz BD, Lozachmeur A, Michuda J, Parsons J, Perera JF, Salahudeen A, Shah KP, Taxter T, Zhu W, White KP
Nat Biotechnol 2019 Nov;37(11):1351-1360
Exome Sequencing-Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants
Manickam K, Buchanan AH, Schwartz MLB, Hallquist MLG, Williams JL, Rahm AK, Rocha H, Savatt JM, Evans AE, Butry LM, Lazzeri AL, Lindbuchler DM, Flansburg CN, Leeming R, Vogel VG, Lebo MS, Mason-Suares HM, Hoskinson DC, Abul-Husn NS, Dewey FE, Overton JD, Reid JG, et al.
JAMA Netw Open 2018 Sep 7;1(5):e182140
The current state of clinical interpretation of sequence variants
Hoskinson DC, Dubuc AM, Mason-Suares H
Curr Opin Genet Dev 2017 Feb;42:33-39
The C terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3'-end processing
Yang F, Hsu P, Lee SD, Yang W, Hoskinson D, Xu W, Moore C, Varani G
RNA 2017 Jan;23(1):98-107
DNA damage induces targeted, genome-wide variation of poly(A) sites in budding yeast
Graber JH, Nazeer FI, Yeh PC, Kuehner JN, Borikar S, Hoskinson D, Moore CL
Genome Res 2013 Oct;23(10):1690-703